Sunday, March 28, 2010
Prospect Workshop Summary
Sunday, February 28, 2010
#5 State of Research Prospectus
#4 Open Topic
Saturday, February 27, 2010
#3 Reading the Literature Review
#2 Open Topic
Sunday, February 21, 2010
#3 Types of Writing in your Field
#5 Open Topic
#4 What did you see on your way to work/school/etc.?
#2 What are your strengths?
#1 Researching/Writing Goals and Aspirations
Thursday, February 18, 2010
Observation and Description Exercise: One hour of interrupted listening
Sunday, February 14, 2010
Article Summary #15
Experts fear that older women are doing away with contraception in belief that they are not able to get pregnant past a certain age. The Family Planning Association (FPA) thinks that the message of infertility and age has put wrong ideas into women’s heads. Although infertility does happen, a woman can still be fertile well into her forties, and even fifties. For England and Wales, the abortion rate for women between 40 and 44 has matched the rates of those girls under 16. In 2008, both of these groups had an abortion rate of 4 out of 1,000 women. A common reason why older women get abortions is because there is more likely for a birth abnormality in the baby. But, FPA says that it is because of the unreliable evidence that women wrongly assume that they could not get pregnant because they are too old.
Aimed for women 35 and over, the FPA is putting on a new campaign ‘Conceivable?’ that reminds women to stay alert about unplanned pregnancies and to keep using the contraception until after menopause if they don’t want to become pregnant. Chief executive of the FPA says that the message of fertility is declining with age is important, its often an inconsistent message. She also says that it sends inaccurate messages to women and society that only the young can get pregnant, and it leads the older women to think their fertility is gone long before it actually is. Women 30 to 34 have the highest fertility rate- 113.1 births per 1,000 women. The rate among 40 year old women has doubled since 1988 from 5.1 to 12.6 per 1,000 births. In 2008, there was 26,000 births to women over 40.
Article Summary #14
Why people with autism do not like hugs could be linked to delays in the development of the brain when the child is still in the womb. A study was done with mice that have fragile X syndrome, and researchers found that the part of the brain that responds to touch is formed late. These findings might be able to explain why people with the condition are hypersensitive to physical contact, and could lead to key stages when treatment is most effective.
Fragile X syndrome is caused when a gene in the X chromosomes interferes with protein production of FMRP. If the gene wasn’t interfered, the protein usually directs the formation of other proteins that build synapses in the brain. Boys usually are more severely affected with this condition, which is in fact the leading cause of autism.
Researchers recorded electrical signals in the brains of the mice and found that something in the sensory cortex was late to mature. The study also found changes in the brain’s connections occur midway through a baby’s development in the womb. This suggests that there could be a window for treatments for fragile X and autism that could be most effective. Autism is common in people with fragile X syndrome, however there are other causes, most of which are not fully understood. But, understanding how the brain works in a person who has fragile X could help put together some ideas about what is going on in the brain when a person has autism.
Article Summary #13
US researchers say that they will know if a child will be obese by the age of two. A study was done on over 100 obese kids and teens and was found that more than half were overweight by 24 months and 90% of them were overweight by the age of five. Right now in the UK, about 27% of kids are overweight. Researchers say that the reason for weight gain is not understood, and can vary from person to person, factors that can lead to being overweight is poor diet, early introduction to solid food, and not getting enough exercise.
Researchers also said that a diet is set for kids by the age of two, so changing the eating behavior at a later stage is difficult. The study leader, Dr. John Harrington, an assistant professor at Eastern Virginia Medical School said: “the results should be a wake-up call for doctors. Too often to doctors wait until health complications are already there before they start their treatment. Getting parents and children to change their eating habits is already a challenge. This study indicated that there needs to be a discussion on weight gain in early infancy to affect meaningful changes in the current obesity trend”.
Wednesday, February 10, 2010
Article Summary #12
Researchers claim that it is possible that extremely overweight people may be missing some of the same genetic material. Some findings say that obesity can be linked to inheritance, but scientists at Imperial College London found dozens of severely obese people who lacked the same 30 genes. This missing gene could not be found in people of normal weight. The latest study focused on the morbidly obese who have a BMI of more than 40 and have high risk health problems. These people are estimated to be 700,000 in the UK.
The first hint was looking at a group of teens and adults with learning disabilities who were known to be at a high risk for obesity. The researchers found 31 people who had the identical “deletions” in their genetic code, all of whom had a BMI of over 30. Most patients had been normal weight at toddlers, but then became overweight later on in their childhood. The precise function of the missing genes is unclear. Dr. Robin Walters said that the particular set of deletions was rare, and it affects 7 in 1,000 morbidly obese people, but there is likely that other variations will be found. Dr. Sadaf Farooqi from Cambridge University said that “there is still an important public health message about diet and exercise, simply blaming people for their obesity is no longer appropriate.”
Tuesday, February 9, 2010
Article Summary #11
Scientists in Cambridge have found that an artificial pancreas can be used to regulate blood sugar in children with Type 1 diabetes. This trial found that combining a “real time” sensor measuring glucose levels with a pump that delivers insulin can boost overnight blood sugar control. The study showed that the device cut the risk of blood sugar levels dropping too low. Type 1 diabetes is a life threatening conditions where the pancreas does not produce insulin.
Seventeen children and teenagers with Type 1 diabetes participated in the study that included 54 nights in the hospital. The glucose monitoring system and the insulin pump used in the study are both already used and commercially available. The problem would be to turn them into a closed loop system. This would have to monitor the patients condition and deliver the treatment accordingly. For this, researchers developed a algorithm to calculate the appropriate amount of insulin to deliver to the body based on real time glucose readings. Then, they measure how well the artificial pancreas system controls the glucose levels compared with the children’s regular continuous pump.
The testing was done in different circumstances to increase the risk of low blood sugar attacks. The results showed the artificial pancreas kept the blood glucose levels in the normal range for 60 percent of the time, compared with 40 percent for the continuous pump. The artificial pancreas halved the time the blood glucose levels fell below 3.9mmol/l. It also prevented blood glucose falling below 3.0mmol/l.
Article Summary #10
The US National Institutes of Health study found the variants in DNA differences which appear to affect the risk of giving birth early in both babies and mothers. Premature births account for 7 percent of UK births. Premature births are inadequately understood, making infections and other medical complications blamed. A study done looked at 700 DNA variants in 190 genes in women who delivered early, and also who carried their baby to term. It was found that the babies who carried a DNA variant for the gene Interleukin 6 receptor were more likely to be born early. Interleukin 6 is produced by cells in response to infection and is involved in inflammation. High levels of this in the amniotic fluid and fetal blood have been linked to the onset of premature labor.
Dr. Romero led the study and said that the hypothesis was that the mother and/or fetus signal the onset of the preterm labor when the environment inside the uterus is unfavorable and threatens the survival of the maternal-fetal pair. The onset of premature labor happens when the infection in the uterus is apparent and the body goes into survival mode. This allows the mother to rid herself of the infection, thus allowing her to have the ability to have future pregnancies.
Article Summary #9
A team of clinical pathologists found that an insulin-like hormone speeds the destruction of bone caused by malignant tumors. If this study is proven true, the results could point to drugs for slowing or stopping the damage to bones caused by cancer. The hormone relaxin has already been tied to cancer, and previous studies linked high levels of this hormone to aggressive endometrial and prostate cancer, as well as breast and thyroid. It still was unclear if relaxin was produced by cancerous tumors and could boost the destruction of bone tissue.
Relaxin belongs to the same class of hormones as the one produced in the testes, INSL 3. It was shown in previous studies that if its placed under a certain condition, INSL 3 interacts with osteoblasts that build up bone tissue. When the testes do not produce enough INSL 3, bone mass drops and osteoporosis occurs. Relaxin was found to trigger a similar effect, and researchers proved it by studying the effects of relaxin on cultured human bone cells. It was found that the hormone stimulates osteoclasts, which removes bone’s excess tissue. By binding with a receptor, relaxin caused the osteoclasts to consume too much bone tissue and release a huge quantity of calcium. Too much calcium into the blood causes hypercalcemia. It was also found by researchers that relaxin promotes growth, separation, and invasiveness of various tumors. Researchers added an anti-relaxin antibody to the cell cultures and resulted that the antibody prevented relaxin from binding with receptors and from causing bone damage. The findings suggest that a drug based on this antibody will inhibit the relaxin receptor and slow down bone damage.
Sunday, February 7, 2010
#3 Survey of Current Topics in Your Field
Dehydration can compromise an athlete’s performance and increase their risk of a heat related illness. Athletes do not voluntarily drink a sufficient enough of water before physical activity to prevent dehydration. An athlete’s actions towards drinking a sufficient amount of fluids can be modified by education, accessibility, and tastiness. This should not be confused to cause overdrinking because that too can be harmful and cause a decrease in physical performance. Athletic trainers provide practical recommendations regarding fluid replacement for athletes.
Management of Sport Related Concussion
Large numbers of athletes participate in sport: youth, high school, recreational, collegiate, and professional. As sports became more popular in the lives of Americans, the responsibility falls on parents, coaches, physicians, and researchers to provide a safe environment to reduce injury. For example, the recommendations made for football between 1976 and 1980 resulted in a significant reduction in fatalities and catastrophic injuries. Certified athletic trainers average about 7 athletes with concussions a year. Many athletes do not know how dangerous a concussion is, and if second impact syndrome happens, possible death. This is why it is important for an athletic trainer to recognize the signs and symptoms, and educate the family with the next steps of how to insure a proper recovery.
Emergency Planning in Athletics
The objective of having an Emergency Action Plan (EAP) is to educate athletic trainers and others about the need for emergency planning, proved guidelines in the development of emergency plans, and to advocate documentation of emergency planning. Potentially life threatening emergencies in athletics are unpredictable, and proper management of these injuries is critical and should be known to minimize the risk to the injured athlete. Emergency plans should be developed by organizational personnel in consultation with the local emergency medical services. Component of the EAP include: identification of the personnel involved, specification of the equipment needed to respond to the emergency, and the establishment of a communication system to summon emergency care. EAP’s should be reviewed and rehearsed annually.
#6 Open Topic
#5 Learning Styles
After taking the survey, the results came up with me being 33% naturalistic, 58% bodily-kinesthetic, 31% musical, 31% interpersonal, 44% intrapersonal, 25% visual-spatial, 31% logical-mathematical, and 33% verbal-linguistic. I am definitely a spatial learner. I like to draw or doodle in class while the teacher is talking, in a weird way it helps me concentrate. I also enjoy engaging in artistic pursuits. Also, with athletic training being my major, I have become a bodily-kinesthetic learner. I am physically active and enjoy the outdoors, I excel at one or more sports, I like working with my hands, I have a need to touch things when learning about them, and need to practice skills by doing them rather than simply reading or hearing about them.
#4 Refine Your Research Topic/Question/Problem
#2 What are you passionate about?
#1 Recent Dream
Article Summary #8
A new study details twenty obese men spent a week near the top of Germany’s highest peak and saw their metabolism speed up, appetite decrease, and had lost more weight here than if they stayed at home. Unfortunately, the study did not have a control group, so the results were inconclusive. Mountain air contains less oxygen, so breathing it causes the heart to beat faster and the body to burn more energy. A couple of studies have found that athletes training at higher altitudes tend to lose more weight than those at lower altitudes.
Lippl, a gastroenterologist of the University of Ludwig-Maximilians-University Munich in Germany, and his colleagues invited these twenty men to a research station 300 meters below the summit of Zugspitze. They wanted to see if the men would lose weight if they weren’t doing any more physical activity than normal. The men could only take the same number of steps each day that they were usually at home, which was monitored by a pedometer, and were also allowed to eat as much as they liked. Blood was taken so the researchers could test for hormones linked to appetite and obesity. Starting at about 105 kg, by the end of the week the men had lost an average of 1.5 kg. Also, the men’s blood pressure had dropped which researchers say was contributed by the loss of weight.
Researchers say that what actually caused the weight loss is uncertain, that a various number of variables can be a factor. Loss of appetite is common at higher altitudes, but the men ate less than normal not only because the loss in appetite, but because the men’s eating were being monitored. Lippl thinks the increased metabolic rate also contributed to the weight loss, but again the variables cannot be separated to see which factor helped with the weight loss.
Wednesday, February 3, 2010
Article Summary #7
There is a new study that provides hope that will open the lines of communication between families and patients in a vegetative state. Researchers say that someone with severe brain injury can answer simple questions by controlling his thoughts to influence the scans of his brain activity. In 2006, researchers, using an MRI, tested a young woman who was diagnosed as being in a vegetative state after being involved in a car accident. She was unresponsive and unaware of her surroundings, but showed patterns of brain activity when she was asked to imagine herself playing tennis or walking in her house.
In the new study, a similar method was used to examine 53 people who were in a vegetative state or slightly less severe conscious state. Researchers found that in four of these patients, distinct patterns of brain activity during the tennis and house imaging task was found that showed some level of awareness that could not be detected by their behavior. A study was done in a 22 year old male who was in a vegetative state for 5 years. Researchers asked him to answer six questions by imagining tennis to indicate a “yes” or the house for a “no”. The questions involved basic questions about himself such as the name of his father, or if he had any brothers or sisters. Researchers reported this method worked 100 percent of the time.
Tuesday, February 2, 2010
Article Summary #6
Findings suggest that taking fish oil supplements can hold off mental illness in people with a high risk of them. A three month study was done where the supplement was taken and appeared to be as effective as drugs, cutting the psychotic illness by a quarter. Researchers believe that omega 3 not only has benefit for healthy hearts, but beneficial effects for the brain. The study authors, who remain unnamed, say that finding this treatment gives hope that psychotic disorders for alternatives to antipsychotic drugs. Antipsychotic drugs are intoxicating and can have serious side effects, which leads to people having to not be able to take them, where fish oil supplements are easily tolerated.
An international team tested 81 people who had a high risk of developing psychosis. High risk meant that there was a strong family history of schizophrenia or similar disorders or the person had already developed mild symptoms of the conditions. In the study, half the individuals took fish oil supplements for 12 weeks, and the other half took a placebo, neither of the groups knowing which treatment they were receiving. The results, after following these participants for a year, were that two in the fish oil group developed a psychotic disorder, and eleven in the placebo group. Based on these results, it was estimated that for every four people treated over a year for psychosis, one high risk adult could be prevented from developing it. Researchers believe that the omega 3 fatty acids found in the supplements can alter the signaling to and from the brain with beneficial effects.
Monday, February 1, 2010
Article Summary #5
It is obvious for oncologists to know that the sooner they can determine whether a treatment is unsuccessful, the sooner they can try and fix it into a new course of action. The bad part is that it usually takes two or more months to compare the before and after to determine if the tumor is shrinking. An Israeli company, Aposense, could have found a way to speed up this process; they have an imaging marker that when its used with PET scans, it indicates which cells are dying.
Apoptosis is the process by which cells commit suicide and is a vital mechanism in the body that picks out damaged or unhealthy cells. These cells that undergo apoptosis have a distinct characteristic that the profile of the membrane changes and the cell becomes more acidic, thus leaving the membrane jumbled. Aposense believes they found a way to let doctors image the cell death that lets them know if the treatment is working or not. This can happen a few days after treatment begins rather than the two months in the previous procedures. The tracer can be delivered to patients when they are in an inactive state, letting the acidic environment surround the apoptotic cells, causing the molecule to activate. The new process recognizes the dying cells by their altered membrane, binds to it, and works its way into the cell. The tracer is then linked to the imaging isotope fluoride to make it easy for PET scans to pick up the signal. The idea with this is that you can see if a patient is getting benefits from the radiation treatment, and quickly change to an alternative treatment if its not.
Sunday, January 31, 2010
Article Summary #4
The big question is do prions- misfolded versions of healthy protein linked to mad cow and other neurological diseases- infect and cause disease all on their own? Five years ago was when the first major evidence that prions act alone. Prusiner, a biochemist, injected the brains of mice with prions, and the mice came down with neurological disease. There were limitations, though, that the mice took more than a year to become ill and had been bred to produce large amounts of the prion protein. This raised questions to whether they were prone to prion disease anyway.
A biochemist at Ohio State University in Columbus fixed the two problems by coaxing prions to misfold like he believes they do naturally. Instead of misfolding the healthy protein, they combined the healthy protein with blends of lipids. With this, 15 mice brains were injected, and within 130 day, all of the mice looked like the prion disease (their heads twitched, they lost muscle tissue, and became lazy). The mice died several months later. To prove it was prion disease, Ma conducted many tests. Will this information be enough to convince skeptics?
Article Summary #3
Six million light years away, astronomers have spotted a star size black hole that has a mass that is 20 times that of the sun. The discovery was made using the Very Large Telescope facility on Mount Paranal in Chile. A professor from Sheffield University said that for the amount of time that it will take the light to reach us, the star will have blown up in a supernova to produce its own black hole. If one was to be at the system right now, they would find a pair of black holes spiraling around each other. Black holes are said to come in two sizes: the super massive size and the stellar sized one. The super massive one is huge and weighs a million to a billion times the mass of the sun. The stellar size one could only be ten times the mass of the sun, and made when big stars exhaust their nuclear fuel and collapse. This new discovery is found to be in the stellar size category.
The companion is something astronomers call a Wolf-Rayet star, a giant, hot, highly-evolved star that is billowing gas into space. A lot of this material is being pulled into the black hole and assuming the Wolf-Rayet arrives at the expected time, then the system will have the two black holes grow together. Merging black holes are considered one of the most promising targets for the experiments.
#7 List of Research Questions/Problems
-Does it actually work?
-Would it do more harm for the body than good?
-Does the hot and cold together really pump out the inflammation?
-What would be a “good” time to have the body part in each bath?
Electrical Stimulation
-Does it really help with pain, or is it a placebo effect?
-If it does help with pain, is it helping the injury itself?
-Does it help in re-educating the muscle when the muscle is hypotrophic?
-Is it effective?
Stretching and injury prevention
-Does stretching prevent injuries?
-Do other factors for injury include being tackled, irregular fields, weak muscles, loose tendons and ligaments?
-Would previous injuries factor into if stretching will help? Or compliance?
-How often do you stretch for it to be effective? Once? More?
-How long do you stretch for it to be effective?
#6 Refined List of Research Topics
2. Electrical stimulation- Electrical stimulation is used in athletic training rooms along with physical therapy clinics. The idea of e-stim is to send an electrical pulse through your body blocking the pain signals from going from the site of pain to your brain. A lot of patients have it in their mind that its actually healing them, research is still unsure of it.
3. Pilates and back pain- Pilates is an exercise routine done to help the core muscles of the body. It is believed that it could help with back pain. I believe it some what because of the position they call “imprinting”. This position is used at physical therapy for patients with back pain. The position is to guard your back from being stressed by closing the arch of your back into the ground. Also, most times the reason why people have low back pain is because their abs need to be tightened. Doing pilates will help strengthen those muscles and therefore help the back pain.
#5 List of Research Topics
2. Technological advances in emergency patient care
3. Does Electrical stimulation work, or is it a placebo effect?
4. Does muscle weigh more than fat
5. Yoga and weight loss
6. Pilates and back pain
7. Does stretching prevent injuries?
#4 Current Major and Career Goals
#3 One significant Person or Significant Event freewrites and expand it
#2B Three Significant Events
The second significant event happened the summer after I graduated high school. I got my first job working at a daycare for kids with autism. I was a junior therapist, which I thought was a pretty awesome job. I worked 4 hours a day, and I helped the therapists with the kids when they went on outings, or field trips. This was significant to me because I saw how rewarding it was to see a child improve over the course of three months. Every summer after that I came back and worked there as a therapist, each summer getting better and better, more rewarding. This is when I started to think that I could do this as a career: teach special education during the day, and after school do athletic training.
The third event happened not too long ago. Still stuck on what I really wanted to do for the rest of my life, I attended a summer intern program at Temple University for podiatry. It was a week long program, including lectures, shadowing podiatrist, and hands on workshops. This workshop was really fun and lead me to believe I could go to medical school and get a specialty in podiatry. After this program, I asked if I could shadow a podiatrist for the rest of the summer. I liked shadowing, but at the end of the summer I realized that its not quite what I want to do for the rest of my life. So the search continues…
#2A Three Significant People
Saturday, January 30, 2010
#1 Earliest Memory
Science Article Summary 2
Carnations, an exotic tropical plant, can be found in a bouquet at the grocery store, especially around Valentine’s Day (hint hint fellas). There has been recent research shown that reveals the flower’s rapidly growing 300 species, many which arose in Europe. It was a surprise to biologists because when something grows at a fast pace, they usually think of exotic places. Europe seemed out of place in this nature because it’s more of a “boring” place. That was until Europe was found to have an unusually high number of carnation species, nearly one third of the world’s varieties. Two years were spent collecting DNA from Dianthus, a carnation genus. Researchers calculated that the genus is as old as 7 million years, and Europe seems to be the hot spot. It’s not sure why the carnations were suddenly booming, but might coincide with climate shift that happened two million years ago. During this, the once humid Mediterranean Basin dried out, created winters to be mild and rainy, summers to be hot and dry, and was thought that while other plant species died out, Dianthus already had some of the traits that helped it grow in that type of climate. An expert in botany explains about the study that “this is a novel finding for European flora…the painstaking task of recreating evolutionary family trees for genera with large numbers of species is well worth the effort.”
Sunday, January 24, 2010
Science Article Summary 1
Doberman pincshers curl up in a ball and suck their flanks for hours at a time. Researchers studied these dogs and seemed to find a gene that is shared with humans. In people, there is an estimate of 2.5 to 8 percent to have the obsessive- compulsive disorder. Characteristics show things like excessive hand washing, repetitive checking of stoves, locks and lights, and damaging actions like pulling their hair out and self confliction. Dr. Dodman and his colleagues searched for a source of this behavior in dogs, and compared the genomes of 94 Doberman pinschers that sucked their flanks or blankets. Dodman also studied pedigrees of all dogs for patterns of inheritance. A spot was found on chromosome 7 that showed variation in the genetic code when the sucking and non sucking dogs were compared. A protein called cadherins were involved in the cell alignment, adhesion and signaling which contained the instructions for sucking. Cadherins were also recently associated with autism which includes the repetitive and compulsive behaviors. Scientists are now working on finding and sequencing the gene in humans to see whether it is linked to obsessive compulsive behavior. As scientists learn more about the causes of this condition, they will increase using the term obsessive compulsive disorder to apply to not only humans, but animals too. Dr. Karen Overall, a veterinarian specializing in animal behavior, suggested that up to 8 percent of dogs in the United States show compulsive behaviors like fence running, pacing, spinning, tail chasing, licking, chewing, and barking. Males outnumber females three to one in dogs, and could be treated, if early enough. Geneticists say that because of the detailed pedigree and their similarity to those of humans, dogs make a good model for studying human behaviors and pathologies.